1-Benzyl-2-(trifluoromethyl)benzimidazole synthesis
- Product Name:1-Benzyl-2-(trifluoromethyl)benzimidazole
- CAS Number:134275-16-4
- Molecular formula:C15H11F3N2
- Molecular Weight:276.26
Yield:134275-16-4 50%
Reaction Conditions:
with potassium phosphate;copper(l) iodide in dimethyl sulfoxide at 120; for 24 h;Sealed tube;Inert atmosphere;
Steps:
2; 5
Add CuI (9.5mg, 0.05mmol) to the 10ml sealed tube,Ligand (0.05mmol), chlorobenzene (0.5mmol) and K3PO4 (175mg, 1.5mmol), vacuum the sealed tube and change argon three times,Use a syringe to add amine (0.75 mmol) and DMSO (1.0 mL) to the sealed tube, seal it well, and react in an oil bath at 120°C for 24 hours. The reaction system was cooled to room temperature, the reaction mixture was poured into ethyl acetate and ammonium chloride aqueous solution, the aqueous phase was extracted with ethyl acetate (3×5ml), the organic phases were combined, and the organic phases were washed with sodium bicarbonate and saturated brine. Drying with anhydrous ammonium sulfate, concentrating under reduced pressure to obtain a crude product, and separating the target product by silica gel column chromatography.
References:
CN112430216,2021,A Location in patent:Paragraph 0050-0052; 0064-0068
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