ChemicalBook CAS DataBase List 1-Benzyl-4-Piperidine acetic acid ethylester

1-Benzyl-4-Piperidine acetic acid ethylester synthesis

9synthesis methods

Product Name:1-Benzyl-4-Piperidine acetic acid ethylester
CAS Number:71879-59-9
Molecular formula:C16H23NO2
Molecular Weight:261.36

59184-90-6 Synthesis

2-(PIPERIDIN-4-YL)-ACETIC ACID ETHYL ESTER

59184-90-6
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$11.00/250mg

100-39-0
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$10.00/10 g

1-Benzyl-4-Piperidine acetic acid ethylester

71879-59-9
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Yield: 90%

Reaction Conditions:

with potassium carbonate in acetonitrile at 85;Inert atmosphere;

Steps:

1 General procedures for the preparation of intermediate
General procedure: A mix of methyl piperidine-4-carboxylate or ethyl 2-(piperidin-4-yl)acetate (10 mmol) in acetonitrile (20 ml), 1a-j (11 mmol),anhydrous K2CO3 (12 mmol) was refluxed under nitrogen for 8 hat 85 C. The mixture was then cooled and filtered and the solvent removed in vacuum. The residue was dissolved in ethyl acetate(50 ml) and washed with water (15 ml). Drying and removal of the solvent followed by chromatography (ethyl acetate/petroleumether = 1:4) afforded desired product 2a-j.

References:

Wang, Jin;Wang, Zhi-Min;Li, Xue-Mei;Li, Fan;Wu, Jia-Jia;Kong, Ling-Yi;Wang, Xiao-Bing [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 18,p. 4324 - 4338]

40110-55-2 Synthesis