![](/CAS/GIF/3612-20-2.gif)
1-Benzyl-4-piperidone synthesis
- Product Name:1-Benzyl-4-piperidone
- CAS Number:3612-20-2
- Molecular formula:C12H15NO
- Molecular Weight:189.25
![4-oxopiperidinium chloride](/CAS/GIF/41979-39-9.gif)
41979-39-9
116 suppliers
$15.00/10mg
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
423 suppliers
$10.00/10g
![1-Benzyl-4-piperidone](/CAS/GIF/3612-20-2.gif)
3612-20-2
485 suppliers
$6.00/10g
Yield:3612-20-2 89.28%
Reaction Conditions:
Stage #1: 4-piperidone hydrochloridewith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.5 h;
Stage #2: benzyl bromide in N,N-dimethyl-formamide at 65; for 14 h;
Steps:
25
A mixture of 4-piperidone monohydrate hydrochloride (2.5 g, 14.56 mmol) and anhydrous potassium carbonate (7 g, 50.64 mmol) in dry DMF (25 mL) was stirred for 30 min at room temperature. Benzyl bromide (2 mL, 16.82 mmol) was added dropwise into the reaction mixture and heated at 65 °C for 14 h. The reaction mixture was cooled to room temperature, filtered and quenched with ice water (25 mL). The resulting mixture was extracted in ethyl acetate (2 x 20 mL) and the combined organic layers were washed with water (2 x 15 mL) followed by brine (20 mL). The organic phase obtained was dried over anhydrous sodium sulphate and evaporated. The crude product obtained was purified by crystallisation using 2 % methanol in chloroform to afford the title compound.Yield: 2.5 g (89.28 %); 1 HNMR (CDCI3, 300MHz): δ 7.34 (m, 4H), 7.29 (m, 1 H), 3.62 (S, 2H), 2.75 (t, 4H), 2.46 (t, 4H).
References:
WO2011/104680,2011,A1 Location in patent:Page/Page column 77-78
![3-[BENZYL-(2-METHOXYCARBONYL-ETHYL)-AMINO]-PROPIONIC ACID METHYL ESTER](/CAS/GIF/793-19-1.gif)
793-19-1
46 suppliers
$41.00/100mg
![1-Benzyl-4-piperidone](/CAS/GIF/3612-20-2.gif)
3612-20-2
485 suppliers
$6.00/10g
![4-Piperidinone](/CAS/GIF/41661-47-6.gif)
41661-47-6
93 suppliers
$45.00/250mg
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
423 suppliers
$10.00/10g
![1-Benzyl-4-piperidone](/CAS/GIF/3612-20-2.gif)
3612-20-2
485 suppliers
$6.00/10g
![N-BENZOYL-4-PIPERIDONE](/CAS/GIF/24686-78-0.gif)
24686-78-0
140 suppliers
$6.00/1g
![1-Benzyl-4-piperidone](/CAS/GIF/3612-20-2.gif)
3612-20-2
485 suppliers
$6.00/10g
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
423 suppliers
$10.00/10g
![4,4-Piperidinediol hydrochloride](/CAS/GIF/40064-34-4.gif)
40064-34-4
366 suppliers
$10.00/5g
![1-Benzyl-4-piperidone](/CAS/GIF/3612-20-2.gif)
3612-20-2
485 suppliers
$6.00/10g