![](/CAS/GIF/206274-13-7.gif)
1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE synthesis
- Product Name:1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE
- CAS Number:206274-13-7
- Molecular formula:C16H30N2O2
- Molecular Weight:282.42
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![Cyclohexylamine](/CAS/20180906/GIF/108-91-8.gif)
108-91-8
585 suppliers
$10.00/5mL
![1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE](/CAS/GIF/206274-13-7.gif)
206274-13-7
31 suppliers
$45.00/50mg
Yield:206274-13-7 50%
Reaction Conditions:
with sodium cyanoborohydride;acetic acid in methanol at 20; pH=6;
Steps:
1 4.2.1. General procedure for the preparation of compound 4a-b
General procedure: To a stirred solution of tert-butyl 4-oxopiperidine-1-carboxylate (200 mg, 0.67 mmol) in anhydrous MeOH (5 mL)was added N-methylcyclohexanamine/cyclohexanamine, NaCNBH3 (166 mg, 2.68 mmol) at room temperature. Themixture was adjusted to pH 6 by acetic acid, and stirred for 3 hours. The mixture quenched by H2O (20 mL), andextracted by DCM. The organic layer was dried over anhydrous MgSO4, filtered and concentrated. The residue waspurified by chromatography on a silica gel column to yield compound 4a-b.
References:
Lv, Kai;Tao, Zeyu;Liu, Qian;Yang, Lu;Wang, Bin;Wu, Shuo;Wang, Apeng;Huang, Menghao;Liu, Mingliang;Lu, Yu [European Journal of Medicinal Chemistry,2018,vol. 151,p. 1 - 8]
![Cyclohexanone](/CAS/GIF/108-94-1.gif)
108-94-1
527 suppliers
$12.00/50g
![4-Amino-1-Boc-piperidine](/CAS/GIF/87120-72-7.gif)
87120-72-7
20 suppliers
$6.00/1g
![1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE](/CAS/GIF/206274-13-7.gif)
206274-13-7
31 suppliers
$45.00/50mg
![Cyclohexylamine hydrochloride](/CAS/GIF/4998-76-9.gif)
4998-76-9
175 suppliers
$7.00/25g
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE](/CAS/GIF/206274-13-7.gif)
206274-13-7
31 suppliers
$45.00/50mg