1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE synthesis
- Product Name:1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE
- CAS Number:206274-13-7
- Molecular formula:C16H30N2O2
- Molecular Weight:282.42
79099-07-3
543 suppliers
$5.00/5g
108-91-8
585 suppliers
$10.00/5mL
206274-13-7
31 suppliers
$45.00/50mg
Yield:206274-13-7 50%
Reaction Conditions:
with sodium cyanoborohydride;acetic acid in methanol at 20; pH=6;
Steps:
1 4.2.1. General procedure for the preparation of compound 4a-b
General procedure: To a stirred solution of tert-butyl 4-oxopiperidine-1-carboxylate (200 mg, 0.67 mmol) in anhydrous MeOH (5 mL)was added N-methylcyclohexanamine/cyclohexanamine, NaCNBH3 (166 mg, 2.68 mmol) at room temperature. Themixture was adjusted to pH 6 by acetic acid, and stirred for 3 hours. The mixture quenched by H2O (20 mL), andextracted by DCM. The organic layer was dried over anhydrous MgSO4, filtered and concentrated. The residue waspurified by chromatography on a silica gel column to yield compound 4a-b.
References:
Lv, Kai;Tao, Zeyu;Liu, Qian;Yang, Lu;Wang, Bin;Wu, Shuo;Wang, Apeng;Huang, Menghao;Liu, Mingliang;Lu, Yu [European Journal of Medicinal Chemistry,2018,vol. 151,p. 1 - 8]
108-94-1
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87120-72-7
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$6.00/1g
206274-13-7
31 suppliers
$45.00/50mg
4998-76-9
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79099-07-3
543 suppliers
$5.00/5g
206274-13-7
31 suppliers
$45.00/50mg