ChemicalBook CAS DataBase List 4-Amino-1-Boc-piperidine

4-Amino-1-Boc-piperidine synthesis

10synthesis methods

Product Name:4-Amino-1-Boc-piperidine
CAS Number:87120-72-7
Molecular formula:C10H20N2O2
Molecular Weight:200.28

4-BENZYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

206273-87-2
80 suppliers
$45.00/50mg

87120-72-7
27 suppliers
$6.00/1g

Yield:87120-72-7 98%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol; under 5320.36 Torr;

Steps:

I.2

To a solution of compound I-b (25 g, 86.09 mmol) in ethanol (500 mL) was added10% palladium on charcoal (8.62 g). The mixture was exposed to 7 atm of hydrogen until all of the starting material was consumed. The charcoal was removed by filtration and the filtrate was concentrated to give the title compound as a white crystalline solid (17 g, 98%).[88] ¹H-NMR(CDCl ): δ 3.90-4.10 (m, 2H), 2.66-2.79 (m, 3H), 1.69-1.73 (m, 2H), 1.38(s, 9H), 1.10-1.21 (m, 2H).

References:

WO2006/115353,2006,A1 Location in patent:Page/Page column 9-10