ChemicalBook CAS DataBase List 1-Bromo-2-methoxy-3-nitro-benzene

1-Bromo-2-methoxy-3-nitro-benzene synthesis

6synthesis methods

Product Name:1-Bromo-2-methoxy-3-nitro-benzene
CAS Number:98775-19-0
Molecular formula:C7H6BrNO3
Molecular Weight:232.03

27684-84-0 Synthesis

27684-84-0
153 suppliers
$9.00/1g

74-88-4
348 suppliers
$15.00/10g

98775-19-0
195 suppliers
$8.00/250mg

Yield:98775-19-0 76%

Reaction Conditions:

with potassium carbonate in acetone for 24 h;Heating / reflux;

Steps:

3.b b) 2-Bromo-6-nitroanisole
A mixture of the compound from Example 2a) (10.8 g; 0.0495 mol.), methyl iodide (3.4 mL; 0.00545 mol.) and potassium carbonate (8.2 g; 0.0592 mol.) in acetone (250 mL) was stirred and heated under reflux for 24 h. [0392] The mixture was evaporated and the residue triturated with water to afford the title compound (8.7 g; 76%). mp 55-56° C. 1H NMR (300 MHz, CDCl3 δ 7.81-7.74 (m, 2H), 7.13 (t, J=8.1 Hz, 1H), 4.02 (s, 3H); Anal. (C7H6NO3Br) calcd: C, 36.24; H, 2.61; N, 6.04. found: C, 36.30; H, 2.59; N, 5.73.

References:

Erickson-Miller, Connie J;Eppley, Daniel F.;Jenkins, Julian;Luengo, Juan I.;Liu, Nannan;Price, Alan T.;Shaw, Anthony N.;Visonneau, Sophie;Wiggall, Kenneth US2004/19190, 2004, A1 Location in patent:Page 18

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13073-25-1 Synthesis