1-Chloro-4-(2-propyn-1-yloxy)-benzene synthesis

5synthesis methods

Product Name:1-Chloro-4-(2-propyn-1-yloxy)-benzene
CAS Number:19130-39-3
Molecular formula:C9H7ClO
Molecular Weight:166.6

13610-02-1 Synthesis

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Yield:-

Reaction Conditions:

with N-chloro-succinimide;chloro-trimethyl-silane in acetonitrile at 20; for 1 h;Overall yield = 157.4 mg; regioselective reaction;

Steps:

General procedure for the electrophilic aromatic halogenation. 4-bromo-2-chloro-1-methoxybenzene (2a-Cl) and 2,4-dichloro-1-methoxybenzene (2a-diCl)
General procedure: To a solution of 4-bromoanisole (200.8 mg, 1.09 mmol, 1.0 equiv) in acetonitrile (2 mL) was added N-chlorosuccinimide(NCS) (158.3 mg, 1.19 mmol, 1.1 equiv) at rt to give a slightly cloudy mixture. Chlorotrimethylsilane (TMSCl) (14 μL, 0.11 mmol, 0.1 equiv) was then added drop-wise to the reaction mixture. Within a few minutes, the reaction mixture became clear pale yellow solution. The mixture continued to stir at rt for 1 h and was diluted with hexane. The biphasic mixture was concentrated on a rotary evaporator to a crude white solid-oil mixture. This mixture was taken up in hexane and filtered through a short plug of SiO2 and eluted with 5-10% EtOAc-hexane solution. The clear filtrate was concentrated to obtain a mixture of 4-bromo-2-chloro-1-methoxybenzene (2a-Cl) and 2,4-dichloro-1-methoxybenzene (2a-diCl) 237.0 mg (88% of 2a-Cl and 11% of 2a-diCl,based on NMR ratio 2a-Cl: 2a-diCl = 7.1: 1.0; as a pale yellow solid).

References:

Maibunkaew, Tapanee;Thongsornkleeb, Charnsak;Tummatorn, Jumreang;Bunrit, Anon;Ruchirawat, Somsak [Synlett,2014,vol. 25,# 12,art. no. ST-2014-U0267-L,p. 1769 - 1775] Location in patent:supporting information

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