1-chloroethyl pivalate synthesis
- Product Name:1-chloroethyl pivalate
- CAS Number:40258-80-8
- Molecular formula:C7H13ClO2
- Molecular Weight:164.63
Yield:40258-80-8 88%
Reaction Conditions:
with zinc(II) chloride at 50; for 16 h;
Steps:
12.a
To a mixture of acetaldehyde (0.84 mL, 16.6 mmol) in zinc chloride (62 mg, 0.45 mmol) was added dropwise 2,2-dimethyl-propionaldehyde (2.05 mL, 16.6 mmol). The mixture was then heated to 50° C. for 16 h. The blackish material was filtered through a plug of silica gel with dichloromethane to afford 2,2-dimethyl-propionic acid 1-chloro-ethyl ester as an oil (2.4 g, 88%) after the removal of dichloromethane under reduced pressure: 1H NMR (300 MHz, CDCl3): δ 6.64-6.59 (m, 1H), 1.82 (d, J=6.7 Hz, 3H), 1.36 (s, 9H).
References:
US2009/28925,2009,A1 Location in patent:Page/Page column 117
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