ChemicalBook CAS DataBase List 1-Chloromethyl naphthalene

1-Chloromethyl naphthalene synthesis

14synthesis methods

Product Name:1-Chloromethyl naphthalene
CAS Number:86-52-2
Molecular formula:C11H9Cl
Molecular Weight:176.64

50-00-0 Synthesis

50-00-0
862 suppliers
$10.00/25g

91-20-3 Synthesis

91-20-3
504 suppliers
$14.00/25g

86-52-2
345 suppliers
$9.00/10g

Yield:86-52-2 97.1%

Reaction Conditions:

with hydrogenchloride;ferric(III) chloride;benzyl-triethyl-ammonium chloride;copper chloride (II) in lithium hydroxide monohydrate at 40; for 3 h;Temperature;

Steps:

1.a; 1.b; 2.a; 2.b; 3.a; 3.b; 4.a; 4.b; 5.a; 5.b; 6.a; 6.b; 1-2

In step a, 128g (1mol) of naphthalene, 60g (2mol) of paraformaldehyde, 3.25g (0.02mol) of FeCl, 2.69g (0.02mol) of CuCl2, 3.42g (0.015mol) of benzyltriethylammonium chloride and the mass of 214.7 g (2.5 mol) of hydrochloric acid solution with a concentration of 42.5% were mixed evenly, the temperature was raised to 40°C and the reaction was maintained for 3 h, the temperature was lowered, and the solution was left to stand for separation. The oil phase was washed twice with 10wt% potassium carbonate solution and water to obtain 1-chlorine Crude methylnaphthalene;In step b, the crude 1-chloromethylnaphthalene was added to 192 g of absolute ethanol, heated to 26 °C to dissolve, then cooled to -5 °C at a rate of 0.5 °C/10min for 2 hours, then filtered and washed with absolute ethanol. , the filter cake was placed in a vacuum drying oven, and dried at 25 mmHg and 35° C. for 5 h to obtain 171.5 g of 1-chloromethylnaphthalene product with a content of 99.6% and a yield of 97.1%.

References:

CN113999086,2022,A Location in patent:Paragraph 0040-0072

4780-79-4 Synthesis