ChemicalBook CAS DataBase List 1-CYCLOPROPYL-1H-IMIDAZOL-4-AMINE

1-CYCLOPROPYL-1H-IMIDAZOL-4-AMINE synthesis

4synthesis methods

Product Name:1-CYCLOPROPYL-1H-IMIDAZOL-4-AMINE
CAS Number:1001354-27-3
Molecular formula:C6H9N3
Molecular Weight:123.16

tert-butyl (1-cyclopropyl-1H-iMidazol-4-yl)carbaMate

1001354-26-2
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$581.00/250mg

1001354-27-3
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Yield:1001354-27-3 59%

Reaction Conditions:

with hydrogenchloride in methanol at 20; for 1 h;

Steps:

237.E

237E. 1-Cyclopropyl-1H-imidazole-4-amine A solution of 237D (0.60 gm, 2.3 mmole) in a 5.0 N solution of HCl in methanol was left stirring at room temperature for 1 hr. This was applied onto a Phenomenex Strata-X-C 33 um cation mixed-mode polymer, flushed with methanol, and the product was eluted with a 2 N solution of ammonia in methanol. Removal of the solvents left 237E, (0.20 gm; 59% yield). ¹H NMR (500 MHz, CDCl₃) δ 0.87 (m, 4H) 3.21 (s, 1H) 6.27 (s, 1H) 7.16 (br s, 1H).

References:

US2008/9497,2008,A1 Location in patent:Page/Page column 104

1193639-02-9
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$248.00/250mg

1001354-27-3
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References

1001354-64-8 Synthesis

ETHYL 1-CYCLOPROPYL-1H-IMIDAZOLE-4-CARBOXYLATE

1001354-64-8
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1001354-27-3
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References

1H-Imidazole-4-carboxylic acid, 1-cyclopropyl-, hydrazide

1001354-24-0
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1001354-27-3
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References