1-Cyclopropyl-1H-pyrazole synthesis
- Product Name:1-Cyclopropyl-1H-pyrazole
- CAS Number:1151814-36-6
- Molecular formula:C6H8N2
- Molecular Weight:108.14
1378847-65-4
0 suppliers
inquiry
927-63-9
200 suppliers
$14.00/1g
1151814-36-6
50 suppliers
$108.00/100mg
Yield:-
Reaction Conditions:
with sodium acetate in ethanol at 70; for 16 h;
Steps:
l-Cyclopropyl-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-lH-pyrazoleCyclopropylhydrazine oxalate (162 mg, 1.00 mmol) and NaOAc (82 mg, 1.0 mmol) were combined in EtOH (200 proof, 1.5 niL) and 3-dimethylamino-propenal (0.10 niL, 1.0 mmol) was added in one portion via syringe. The suspension was stirred at 70 0C for 16 h then allowed to cool to room temperature. The reaction was diluted with sat. aq. NaHCθ3 (3 mL) and extracted with EtOAc (4 x 5 mL). The combined organic layers were dried over Na2Sθ4 and concentrated on a rotary evaporator without heating the sample to give the 1 -cyclopropyl- lH-pyrazole as a volatile, liquid that was used without further purification, m/z 109.4 [M + H]+
References:
WO2010/141273,2010,A1 Location in patent:Page/Page column 52-53
288-13-1
414 suppliers
$10.00/1g
411235-57-9
434 suppliers
$6.00/1g
1151814-36-6
50 suppliers
$108.00/100mg