1-Cyclopropyl-4-iodopyridin-2(1H)-one synthesis
- Product Name:1-Cyclopropyl-4-iodopyridin-2(1H)-one
- CAS Number:1193335-00-0
- Molecular formula:C8H8INO
- Molecular Weight:261.0597
858839-90-4
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Yield:1193335-00-0 81%
Reaction Conditions:
with copper diacetate;sodium carbonate in 1,2-dichloro-ethane at 70; for 18 h;
Steps:
85.1
A mixture of 4-iodopyridin-2(1H)-one (0.2425 g, 1.10 mmol, 1.0 equiv), Cu(OAc)2 (0.2146 g, 1.18 mmol, 1.07 equiv), bipyridine (0.1832 g, 1.17 mmol, 1.07 equiv), cyclopropylboronic acid (0.2122 g, 2.47 mmol, 2.25 equiv) and Na2CO3 (0.2638 g, 2.49 mmol, 2.27 equiv) in dichloroethane (10 mL) was stirred at 70° C. for 18 h. The reaction mixture was quenched with satd aq NH4Cl, diluted with CH2Cl2, and dried over Na2SO4. After the solvent was removed under reduced pressure, the residue was purified by chromatography on silica gel eluted with hexanes/ethyl acetate to afford 0.2309 g (81%) of 1-cyclopropyl-4-iodopyridin-2(1H)-one.
References:
US2010/331320,2010,A1 Location in patent:Page/Page column 96
858839-90-4
89 suppliers
$52.00/250mg
142-71-2
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$5.00/10g
411235-57-9
426 suppliers
$6.00/1g
1193335-00-0
2 suppliers
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