![](/CAS/GIF/20327-23-5.gif)
1-Cyclopropylpiperazine synthesis
- Product Name:1-Cyclopropylpiperazine
- CAS Number:20327-23-5
- Molecular formula:C7H14N2
- Molecular Weight:126.2
![1-CYCLOPROPYLPIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/77278-34-3.gif)
77278-34-3
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![1-Cyclopropylpiperazine](/CAS/GIF/20327-23-5.gif)
20327-23-5
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Yield:20327-23-5 59.7%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 3 h;
Steps:
88
A solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) in 4M HCl in 1,4-dioxane (4.37 mL, 17.50 mmol) was stirred at room temperature for 3 h under nitrogen. The reaction mixture was filtered and washed with ether to afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid. The crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 3.5M NH3/MeOH and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.264 g, 59.7%) as a yellow oil. 1H NMR (399.9 MHz, DMSO-d6) δ 0.25-0.30 (2H, m), 0.35-0.40 (2H, m), 1.54-1.60 (1H, m), 2.43 (4H, t), 2.60-2.65 (4H, t), 3.30 (1H, s)
References:
ASTRAZENECA AB US2008/153812, 2008, A1 Location in patent:Page/Page column 117