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1-CYCLOPROPYLPIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis

4synthesis methods
1-methoxy-1-[(trimethylsilyl)oxy]cyclopropane

84098-43-1
4 suppliers
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57260-71-6 Synthesis
1-BOC-Piperazine

57260-71-6
738 suppliers
$5.00/5g

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Yield:77278-34-3 100%

Reaction Conditions:

with sodium cyanoborohydride;acetic acid in tetrahydrofuran;methanol at 63; for 16 h;

References:

Zaragoza, Florencio;Stephensen, Henrik;Knudsen, Sanne M.;Pridal, Lone;Wulff, Birgitte S.;Rimvall, Karin [Journal of Medicinal Chemistry,2004,vol. 47,# 11,p. 2833 - 2838]

57260-71-6 Synthesis
1-BOC-Piperazine

57260-71-6
738 suppliers
$5.00/5g

411235-57-9 Synthesis
Cyclopropylboronic acid

411235-57-9
434 suppliers
$6.00/1g