ChemicalBook CAS DataBase List 1-ETHYL-3-PHENYLUREA

1-ETHYL-3-PHENYLUREA synthesis

14synthesis methods

Product Name:1-ETHYL-3-PHENYLUREA
CAS Number:621-04-5
Molecular formula:C9H12N2O
Molecular Weight:164.2

103-71-9
3 suppliers
$20.19/5g

75-04-7
378 suppliers
$10.00/20mg

621-04-5
28 suppliers
$45.00/100mg

Yield:621-04-5 98%

Reaction Conditions:

in dichloromethane at 0 - 20; for 16 h;

Steps:

Step 1: 1-ethyl-3-phenylurea.

Prepared according to literature procedure. To stir a solution of ethylamine (676.05 μL, 12 mmol) in CH₂Cl₂ (44.0 mL) at 0 °C for 10 minutes was added slowly phenylisocyanate (1,100 μL, 10.1 mmol). The reaction mixture was stirred at 0 °C to room temperature for 16 hours to provide coloress mixture, washed with 2M HCl two times, then extracted with CH₂Cl₂. The organic layer was washed with brine, dried over anhydrous Na₂SO₄, filtered and concentrated. The white solid of 1-ethyl-3-phenylurea was obtained in 1,620 mg (98% yield). ¹H NMR (300 MHz, CDCl₃) δ 7.28 (d, J = 4.2 Hz, 3H), 7.10-7.02 (m, 1H), 6.91 (s, 1H), 5.16 (brs, 1H), 3.26 (q, J = 7.2 Hz, 2H), 1.71 (brs, 1H), 1.12 (t, J = 7.2 Hz, 3H). Other data was identical to the literature values.

References:

Duangjan, Chanikan;Rukachaisirikul, Vatcharin;Saithong, Saowanit;Kaeobamrung, Juthanat [Tetrahedron Letters,2018,vol. 59,# 39,p. 3537 - 3540] Location in patent:supporting information

591-50-4 Synthesis