1-ETHYL-3-PHENYL-2-THIOUREA synthesis

7synthesis methods

Product Name:1-ETHYL-3-PHENYL-2-THIOUREA
CAS Number:2741-06-2
Molecular formula:C9H12N2S
Molecular Weight:180.27

103-72-0
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$10.00/1g

75-04-7
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$10.00/20mg

2741-06-2
17 suppliers
$25.00/1g

Yield:2741-06-2 95%

Reaction Conditions:

in dichloromethane at 20; for 6 h;

Steps:

Preparation of Thioureas 3a-z

General procedure: Method A; To a solution of isothiocyanate 1 (1.0 mmol) in dichloromethane(10 mL) was added the corresponding amine 2(1.2 mmol), and the mixture was stirred at room temperatureuntil isothiocyanate was consumed (TLC). After that, the organicphase was washed with 5% aqueous hydrochloric acid (3×10 mL), dried with anhydrous sodium sulfate and evaporatedin a rotary evaporator to afford the pure thiourea 3, whichdid not require any further purification.

References:

Viana, Gil Mendes;Do Amaral, Lilian Henriques;Meireles, Paloma Wetler;Nunes, Raquel Pinto;Da Silva, Luiz Cláudio Rodrigues Pereira;De Sousa, Valeria Pereira;Sathler, Plínio Cunha;Cabral, Lucio Mendes;Soares, Deivid Costa;Saraiva, Elvira Maria;Santana, Marcos Vinicius;Castro, Helena Carla;De Sequeira Aguiar, Lúcia Cruz;Rodrigues, Carlos Rangel;Abreu, Paula Alvarez [Chemical and pharmaceutical bulletin,2017,vol. 65,# 10,p. 911 - 919]