ChemicalBook CAS DataBase List N,N'-Diethylthiourea

N,N'-Diethylthiourea synthesis

7synthesis methods

Product Name:N,N'-Diethylthiourea
CAS Number:105-55-5
Molecular formula:C5H12N2S
Molecular Weight:132.23

75-15-0
233 suppliers
$40.00/100 g

75-04-7
372 suppliers
$10.00/20mg

105-55-5
328 suppliers
$6.00/25g

Yield:105-55-5 99%

Reaction Conditions:

in water at 20; for 0.166667 h;Green chemistry;

Steps:

1,3-diethylthiourea
General procedure: To a 50 mL round bottom flask equipped with a magnetic stirrer, add carbon disulphide (5 mmol) andamine (10 mmol) in ice cold condition followed by addition of water (5 mL). Cork the flask. Thereaction mixture was stirred vigorously at room temperature. The progress of the reaction was checkedby TLC (10% MeOH: chloroform or EtOAc: hexane). After completion of reaction, solid was obtainedby removal of water under reduced pressure on rotary evaporator while in some cases (Entry 7, 9, 10,11 and 14, 15) the reaction mixture solidified when the reaction on completion. The obtained solidproduct was recrystallized with ethanol or washing with mixture EtOAc: hexane.

References:

Jangale, Asha D.;Kumavat, Priyanka P.;Wagh, Yogesh B.;Tayade, Yogesh A.;Mahulikar, Pramod P.;Dalal, Dipak S. [Synthetic Communications,2015,vol. 45,# 2,p. 236 - 244] Location in patent:supporting information

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