1-ISOPROPYL-PIPERIDIN-4-YLAMINE synthesis
- Product Name:1-ISOPROPYL-PIPERIDIN-4-YLAMINE
- CAS Number:127285-08-9
- Molecular formula:C8H18N2
- Molecular Weight:142.24
![Carbamic acid, [1-(1-methylethyl)-4-piperidinyl]-, phenylmethyl ester (9CI)](/CAS/20200515/GIF/609804-23-1.gif)
609804-23-1
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127285-08-9
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Yield: 98%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen at 20; under 760.051 Torr; for 20 h;
Steps:
1-Cyclohexylpyrrolidin-3-amine I-6
General procedure: To a solution of compound I-5 (240 mg) in HFIP (8 mL), 10% Pd/C (120 mg) was added and thenthe reaction mixture was stirred under H2 at room temperature and 1atm for 20 h. Then themixture was filtrated and the filtrate was concentrated to give compound I-6 as yellow oil (100 mg,75%).
References:
Zhou, Jie;Ji, Ming;Zhu, Zhixiang;Cao, Ran;Chen, Xiaoguang;Xu, Bailing [European Journal of Medicinal Chemistry,2017,vol. 132,p. 26 - 41] Location in patent:supporting information
534595-37-4
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127285-08-9
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73874-95-0
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127285-08-9
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220394-97-8
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127285-08-9
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87120-72-7
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127285-08-9
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