1-(isoquinolin-1-yl)hydrazine synthesis
- Product Name:1-(isoquinolin-1-yl)hydrazine
- CAS Number:15793-94-9
- Molecular formula:C9H9N3
- Molecular Weight:159.19
19493-44-8
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Yield:15793-94-9 92%
Reaction Conditions:
with hydrazine hydrate in ethanol;Reflux;
Steps:
General procedure for the synthesis of 2-hydrazinylpyridine and derivatives (1b-1v)
General procedure: To 2-chloropyridine (1.1 mmol) in ethanol (5.0 mL) was added hydrazine hydrate (2 mL) dropwise at room temperature. The mixture was refluxed until completion as monitored by TLC. The reaction mixture was cooled, ethanol was removed by evaporation. Then, the residue was partitioned between ethyl acetate and water. The combined organic phase was dried over anhydrous sodium sulfate and concentrated to give the product, which was used for the following cyclization reaction without purification.
References:
Liu, Lingfeng;Qiao, Chunhua;Shen, Bei;Xu, Yiwen [Tetrahedron Letters,2020] Location in patent:supporting information
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119-65-3
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