1-Methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde synthesis

Yield:63486-86-2 56 mg

Reaction Conditions:

in acetonitrile at 140 - 170; for 1 h;Microwave irradiation;

Steps:

21-23 Reference Example 21-23

A solution of 6-methoxypicolinic aldehyde (500 mg) and methyl iodide (202 μL) in acetonitrile (1.5 mL) was irradiated with microwaves (microwave reaction apparatus, 140° C., 0.5 hours→170° C., 0.5 hours, 2.45 GHz, 0 W to 240 W). The reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure, and the obtained residues were purified by silica gel column chromatography (hexane:ethyl acetate=1:1→0:1), whereby 1-methyl-6-oxo-1,6-dihydro pyridine-2-carbaldehyde (56 mg) was obtained

References:

US2016/168139,2016,A1 Location in patent:Paragraph 1058; 1059