![](/CAS/GIF/17614-10-7.gif)
(1-Methylethyl)carbaMic Acid Phenyl Ester synthesis
- Product Name:(1-Methylethyl)carbaMic Acid Phenyl Ester
- CAS Number:17614-10-7
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
Yield:17614-10-7 80.6%
Reaction Conditions:
Stage #1: isopropylamine;phenyl chloroformate in n-heptane at 0 - 4; for 1 h;
Stage #2: in n-heptane;water at 0 - 70;
Steps:
1
Example 1; Phenyl N-isopropylcarbamate; A 1-L reactor was charged with isopropylamine (19.3 g, 0.33 mol) and heptane (196 g) and filled with nitrogen. A solution of phenyl chloroformate, (50.0 g, 0.32 mol) in heptane (34 g) was added dropwise to the stirred mixture at 0-4 °C. The obtained mixture was stirred for an hour at the same temperature. A solution of sodium hydroxide (11. 7 g, 0.29 mol) in water (77 g) was added dropwise to the stirred mixture at 0-4 °C. The mixture was stirred at 60-70 °C until a complete dissolution. The organic layer was isolated, washed with hot water (78 g) at 60-70 °C and stirred for 2 hours at 0-5 °C. The precipitated solids were filtered off, washed on the filter with heptane (50 g), dried under reduced pressure at 40-50 °C (water bath) to give 46.1 g (80.6 %) of phenyl N-isopropylcarbamate with mp 81-82 °C and 99.7 % purity by GC.
References:
WO2003/97603,2003,A1 Location in patent:Page/Page column 30
![Isopropyl isocyanate](/CAS/GIF/1795-48-8.gif)
1795-48-8
173 suppliers
$24.73/250mgs:
![Phenol](/CAS/20180808/GIF/108-95-2.gif)
108-95-2
725 suppliers
$14.00/25g
![(1-Methylethyl)carbaMic Acid Phenyl Ester](/CAS/GIF/17614-10-7.gif)
17614-10-7
27 suppliers
inquiry
![Phenyl salicylate](/CAS/GIF/118-55-8.gif)
118-55-8
406 suppliers
$6.00/25g
![Isopropyl isocyanate](/CAS/GIF/1795-48-8.gif)
1795-48-8
173 suppliers
$24.73/250mgs:
![(1-Methylethyl)carbaMic Acid Phenyl Ester](/CAS/GIF/17614-10-7.gif)
17614-10-7
27 suppliers
inquiry
![2H-1,3-Benzoxazine-2,4(3H)-dione, 3-(1-methylethyl)-](/CAS/20210305/GIF/159977-54-5.gif)
159977-54-5
0 suppliers
inquiry
![Phenyl chloroformate](/CAS/GIF/1885-14-9.gif)
1885-14-9
331 suppliers
$10.00/1g
![(1-Methylethyl)carbaMic Acid Phenyl Ester](/CAS/GIF/17614-10-7.gif)
17614-10-7
27 suppliers
inquiry