1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER synthesis

12synthesis methods

Product Name:1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER
CAS Number:56999-62-3
Molecular formula:C13H15NO2
Molecular Weight:217.26

Butanoic acid, 4-(methylphenylamino)-3-oxo-, ethyl ester

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1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER

56999-62-3
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$634.00/5g

Yield:56999-62-3 72%

Reaction Conditions:

at 120; for 0.666667 h;Microwave irradiation;Sealed tube;Green chemistry;

Steps:

3.2. General Procedure for the Synthesis of Indoles and Pyrrolo[3,2,1-ij]quinolones

General procedure: A mixture of α-amino arylethanone (1a) (0.6 mmol) in HFIP (3 mL) was sealed in a pressure vesseltube, and was stirred at 120 °C under microwave irradiation for 40 min. After the reaction finished,the crude reaction mixture was diluted with EtOAc (5 mL), and filtered through a short pad of celite.The sealed tube and celite pad were washed with an additional 20 mL of EtOAc. The filtrate wasconcentrated in vacuo, and the resulting residue was purified by flash column chromatography usinghexanes and EtOAc as the eluent (NMR spectra for all compounds shown in Supplementary Materials).

References:

Yao, Guangkai;Zhang, Zhi-Xiang;Zhang, Cheng-Bei;Xu, Han-Hong;Tang, Ri-Yuan [Molecules,2018,vol. 23,# 12,art. no. 3317]