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4730-77-2

1-NAPHTHYLMETHYLPHOSPHONIC ACID synthesis

3synthesis methods
-

Yield:4730-77-2 75%

Reaction Conditions:

Stage #1: 1-naphthalene methanolwith tris-(dibenzylideneacetone)dipalladium(0);hypophosphorous acid;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene in N,N-dimethyl-formamide at 110; for 15 h;Inert atmosphere;
Stage #2: in N,N-dimethyl-formamide at 110; for 8 h;

References:

Coudray, Laetitia;Montchamp, Jean-Luc [European Journal of Organic Chemistry,2008,# 24,p. 4101 - 4103] Location in patent:supporting information; experimental part