1-Phenyl-3-piperidin-4-ylurea synthesis
- Product Name:1-Phenyl-3-piperidin-4-ylurea
- CAS Number:61220-48-2
- Molecular formula:C12H17N3O
- Molecular Weight:219.28
Yield:-
Reaction Conditions:
with hydrogen;palladium on charcoal in water;acetic acid;benzene;
Steps:
14 EXAMPLE 14
To the solution of 25 g of 4-aminopyridine in 150 ml of benzene is added dropwise with stirring the solution of 31.6 g of phenylisocyanate in 50 ml. of benzene at 40°. After one hour, the pure crystalline 1-phenyl-3-(4-pyridyl)-urea is filtered off, m.p. 155°-156°. 5 g thereof are hydrogenated over 5 g of 10% palladium on charcoal in 80 ml of acetic acid at 70° and 2.7 atm. After the absorption of 3 molar equivalents of hydrogen (2 days) the mixture is filtered and the filtrate evaporated. The residue is taken up in water, extracted with methylene chloride, the extract evaporated and the residue recrystallized from acetone, to yield the 4-(3-phenylureido)-piperidine melting at 172°-175°.
References:
US4073911,1978,A
87120-72-7
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