![](/CAS/GIF/933709-26-3.gif)
1-Phenyl-3-pyrrolidinecarboxylic acid synthesis
- Product Name:1-Phenyl-3-pyrrolidinecarboxylic acid
- CAS Number:933709-26-3
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
![3-Pyrrolidinecarboxylic acid, 1-
phenyl-, methyl ester](/CAS/20180629/GIF/122079-53-2.gif)
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![1-Phenyl-3-pyrrolidinecarboxylic acid](/CAS/GIF/933709-26-3.gif)
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Yield:933709-26-3 84%
Reaction Conditions:
Stage #1: methyl 1-phenylpyrrolidine-3-carboxylatewith sodium hydroxide at 20; for 1.5 h;
Stage #2: with sodium hydrogen sulfate
Steps:
59
INTERMEDIATE 59 - PREPARATION OF i-phenylpyrrolidine-3-carboxylic acid.; The intermediate 58 (0.15 g; 0.709 mmol) was dissolved in a solution of sodium hydroxide 2M (5 ml_). The resulting mixture was stirred at room temperature for 1.5 h and acidified with sodium hydrogen sulfate. The resulting solution was extracted with ethyl acetate, dried and concentrated under reduced pressure to afford 0.156 g (84%) of 1- phenylpyrrolidine-3-carboxylic acid as a pale rose solid which was used without further purification.
References:
WO2010/142801,2010,A1 Location in patent:Page/Page column 164
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