ChemicalBook CAS DataBase List 1-phenylguanidine

1-phenylguanidine synthesis

10synthesis methods

Product Name:1-phenylguanidine
CAS Number:2002-16-6
Molecular formula:C7H9N3
Molecular Weight:135.17

420-04-2 Synthesis

420-04-2
342 suppliers
$15.00/25g

62-53-3 Synthesis

62-53-3
637 suppliers
$10.00/1g

2002-16-6
29 suppliers
$152.00/1g

Yield: 95%

Reaction Conditions:

with scandium tris(trifluoromethanesulfonate) in water at 100; for 12 h;Reagent/catalyst;

Steps:

General Procedure for the Guanylation of Amines:
General procedure: To a solution of p-methoxyaniline (1b, 61.6 mg, 0.50 μmol)and cyanamide (25.2 mg, 0.60 μmol) in H2O (2.5 mL) wasadded Sc(OTf)3 (24.6 mg, 50 nmol) at r.t. After the solutionwas stirred at 100 °C for 2 d, the resulting mixture waswashed with CHCl3 (3 × 10 mL). The aqueous layer wasconcentrated in vacuo, and the residue was purified by filtering through silica gel pad (CHCl3-MeOH, 20:1).

References:

Tsubokura, Kazuki;Iwata, Takayuki;Taichi, Misako;Kurbangalieva, Almira;Fukase, Koichi;Nakao, Yoichi;Tanaka, Katsunori [Synlett,2014,vol. 25,# 9,p. 1302 - 1306]