2-Chloro-1-(4-methylphenyl)-1-propanone synthesis
- Product Name:2-Chloro-1-(4-methylphenyl)-1-propanone
- CAS Number:69673-92-3
- Molecular formula:C10H11ClO
- Molecular Weight:182.65
27816-36-0
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Yield:69673-92-3 91%
Reaction Conditions:
with tin(ll) chloride at 5; for 14 h;Reflux;Temperature;Concentration;
Steps:
3 Example 3
Equipped with a stirrer, thermometer, reflux condenser, dropping funnel in the reaction container, adding stannous chloride 2.43mol, toluene 1.2L, reducing the temperature of the solution to 5 °C, dropwise 2-chloroprop amide 2.1mol were added. The dropping time was controlled at 3 h and the stirring speed was maintained at 180 rpm for 9 h, then mixture was poured into the 2L the mass fraction of 25% sodium chloride solution, the temperature of the solution is reduced to 4 °C, separating the organic layer, the water layer is extracted with toluene 6 time, combined with the organic layer, used for quality score for sequentially 40% solution of sodium carbonate, sodium sulfate solution, 1.8kPa vacuum distillation, to obtain oil solvent is recovered, reducing the temperature of the solution to 12 - - 15°C, precipitated solid, by adding the mass fraction is 98% cyclohexane solution, maintaining the stirring speed 230rpm, filtering, active alumina dehydration, get white solid 1-P-tolyl-2-chloro-1-propanone 349.71g, yield 91%.
References:
CN105481665,2016,A Location in patent:Paragraph 0015; 0016
5337-93-9
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7623-09-8
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![Benzene, 1-[(1Z)-1-chloro-1-propen-1-yl]-4-methyl-](/CAS/20210305/GIF/73496-70-5.gif)
73496-70-5
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69673-92-3
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25574-04-3
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