![](/CAS/20180703/GIF/1240297-66-8.gif)
1-(propylsulfonyl)-3-Azetidinol synthesis
- Product Name:1-(propylsulfonyl)-3-Azetidinol
- CAS Number:1240297-66-8
- Molecular formula:C6H13NO3S
- Molecular Weight:179.24
![1-Propanesulfonyl chloride](/CAS/GIF/10147-36-1.gif)
10147-36-1
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$5.00/5g
![3-Hydroxyazetidine hydrochloride](/CAS/GIF/18621-18-6.gif)
18621-18-6
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$8.00/5g
![1-(propylsulfonyl)-3-Azetidinol](/CAS/20180703/GIF/1240297-66-8.gif)
1240297-66-8
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Yield:-
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 0 - 20;
Steps:
83.1
83.1 1 -(Propane-1 -sulfonyl)-azetidin-3-ol; To a cooled solution (0-50C) of azetidin-3-ol hydrochloride (1 g, 9,13 mmol) in 10 ml di- chloromethane containing diisopropyl ethyl amine (2,391 ml, 13,69 mmol) was added dropwise a solution of propane-1 -sulfonyl chloride (1 ,126 ml, 10,04 mmol) dissolved in 5 ml dichloromethane over an 1 h period. The mixture was allowed to warm up to room temperature and was stirred over night. Citric acid (10%) was added, extracted with dichloromethane, dried over MgSO4, filtered and the solvent was evaporated to obtain 597 mg of a yellow oil, which was purified by chromatography (yield 470 mg)
References:
WO2010/92180,2010,A1 Location in patent:Page/Page column 139