1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID
- CAS Number:77556-50-4
- Molecular formula:C9H7N3O2
- Molecular Weight:189.17
171193-35-4
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77556-50-4
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Yield:77556-50-4 96%
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran;ethanol at 0 - 20; for 7 h;
Steps:
B.65.2
Step 2: 1-Pyridin-2-yl-1H-pyrazol-4-carboxylic acidPyridin-2-yl-1H-pyrazol-4-carboxylic acid ethyl ester (0.81 g, 3.73 mmol) was dissolved in a THF/ethanol (50 ml/10 ml) mixture, cooled to 0° C. and treated with lithium hydroxide (11.2 ml, 1N aqueous solution). The reaction mixture was allowed to warm-up to ambient temperature and subsequently stirred at that temperature for 7 h. The reaction mixture was extracted with dichloromethane (4×100 ml) and the combined organic phases were dried and evaporated to yield the product as white solid (0.68 g, 96%) which was used without any further purification.MS: M=188.2 (M-H)-
References:
US2011/183979,2011,A1 Location in patent:Page/Page column 40-41
109-09-1
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25700-11-2
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77556-50-4
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28469-29-6
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77556-47-9
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77556-50-4
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