ChemicalBook CAS DataBase List 2-PYRAZOL-1-YL-PYRIDINE

2-PYRAZOL-1-YL-PYRIDINE synthesis

13synthesis methods

Product Name:2-PYRAZOL-1-YL-PYRIDINE
CAS Number:25700-11-2
Molecular formula:C8H7N3
Molecular Weight:145.16

288-13-1
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$10.00/1g

1120-90-7 Synthesis

1120-90-7
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$5.00/250mg

25700-11-2
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$23.00/250mg

Yield: 94%

Reaction Conditions:

with copper(l) iodide;manganese(II) fluoride;(1R,2R)-1,2-diaminocyclohexane;potassium hydroxide in water at 100; for 48 h;

Steps:

General procedure for N-arylation of nitrogen nucleophiles
General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999% purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98% purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.

References:

Teo, Yong-Chua;Yong, Fui-Fong;Lim, Gina Shiyun [Tetrahedron Letters,2011,vol. 52,# 52,p. 7171 - 7174] Location in patent:supporting information; experimental part

288-13-1
420 suppliers
$10.00/1g

109-04-6 Synthesis