1-TRIMETHYLSILYL-2-PYRROLIDINONE synthesis
- Product Name:1-TRIMETHYLSILYL-2-PYRROLIDINONE
- CAS Number:14468-90-7
- Molecular formula:C7H15NOSi
- Molecular Weight:157.29
616-45-5
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14468-90-7
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Yield:-
Reaction Conditions:
with chloro-trimethyl-silane;triethylamine in toluene
Steps:
20 Preparation of 1-Trimethylsilyl-2-pyrrolidinone
Preparation of 1-Trimethylsilyl-2-pyrrolidinone Chlorotrimethylsilane (TMSCl, 56.0 mL, 441 mmol) is added dropwise to a solution of 2-pyrrolidinone (30.4 mL, 400 mmol), triethylamine (70.0 mL, 502 mmol) and toluene (400 mL) at room temperature. After stirring at room temperature with a mechanical stirrer for 20 minutes, the mixture is heated at 50° C. for 4 hours. After cooling, the mixture is diluted with hexane (300 mL) and stirred for 30 minutes at room temperature. The mixture is filtered and the filtrate concentrated. Distillation of the residue (1 mm, 68+-74° C.) gives 50.0 g (94%) of the title compound as an oil. 1 H NMR (300 MHz, d5 -pyridine) δ 3.17, 2.26, 1.70-1.85, 0.32.
References:
Pharmacia & Upjohn Company US5712300, 1998, A
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$14.00/5g
14468-90-7
75 suppliers
$49.20/10g
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