cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester synthesis
- Product Name:cis-2,6-Dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester
- CAS Number:1005397-64-7
- Molecular formula:C12H21NO3
- Molecular Weight:227.3
24424-99-5
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1005397-64-7
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Yield:1005397-64-7 73%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 12 h;
Steps:
5.C Step C: tert-butyl-cis-2,6-dimethyl-4-oxopiperidine- 1 -carboxylate.
Di-tert-butyl dicarbonate (3.14 g, 14.4 mmol) and N,N-diisopropylethylamine (3.124 mmol) were added to a solution of cis- 1 -(4-methoxybenzyl)-2,6-dimethylpiperidin- 4-one (1.54 g, 12 mmol) in dichloromethane (30 mL) and the mixture was stirred at room temperature for 12 hr. Solvent was removed under reduced pressure and the residue was purified by silica gel chromatography with hexane/ethyl acetate (8/2, v/v) to afford thecompound (2.0 g, 73 % yield) as a white solid. ‘H NIvIR (400 MHz, CDC13) 4.41- 4.39 (m, 2H), 2.85 (dd, J= 17.8, 6.5 Hz, 2H), 2.37 (dd, J= 17.8, 1.9 Hz, 2H), 1.50 (s, 9H), 1.25 (d, J= 6.8 Hz, 6H).
References:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;WANG, Shaomeng;CHEN, Jianyong WO2018/44767, 2018, A2 Location in patent:Paragraph 0174; 0175
198211-15-3
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