![](/CAS/20150408/GIF/478841-10-0.gif)
tert-butyl 3-hydroxyazepane-1-carboxylate synthesis
- Product Name:tert-butyl 3-hydroxyazepane-1-carboxylate
- CAS Number:478841-10-0
- Molecular formula:C11H21NO3
- Molecular Weight:215.29
![N-BOC-3-AZA-HEPTAN-1-ONE](/CAS/GIF/870842-23-2.gif)
870842-23-2
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$80.00/250mg
![tert-butyl 3-hydroxyazepane-1-carboxylate](/CAS/20150408/GIF/478841-10-0.gif)
478841-10-0
40 suppliers
$175.00/100mg
Yield:478841-10-0 87%
Reaction Conditions:
with methanol;sodium tetrahydroborate at 0;
Steps:
51 Compound 53-6
To a solution of compound 53-5 (5.5 g, 25.8 mmol) in MeOH (55 mL) was added slowly sodium borohydride (NaBH4) (0.98 g, 25.8 mmol) in portions at 0° C. After TLC indicated the reaction was complete, the reaction solution was adjusted to pH 5 to 6 with HCl solution, followed by filtration and extraction with DCM (100 mL×3). The organic phase was dried over anhydrous Na2SO4, filtered and evaporated to give the title compound 53-6 (oil, 4.8 g, Yield 87%). 1H NMR (400 MHz, d6-DMSO): δ ppm 3.95-3.93 (m, 1H), 3.71-3.62 (m, 2H), 3.40 (m, 1H), 3.32-3.28 (m, 1H), 3.03 (m, 1H), 1.88-1.65 (m, 4H), 1.55-1.36 (m, 11H)
References:
Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.;Humanwell Healthcare (Group) Co., Ltd.;Wang, Xuehai;Wu, Chengde;Xu, Yong;Shen, Chunli;Li, Li'e;Hu, Guoping;Yue, Yang;Li, Jian;Guo, Diliang;Shi, Nengyang;Huang, Lu;Chen, Shuhui;Tu, Ronghua;Yang, Zhongwen;Zhang, Xuwen;Xiao, Qiang;Tian, Hua;Yu, Yanping;Chen, Hailiang;Sun, Wenjie;He, Zhenyu;Shen, Jie;Yang, Jing;Tang, Jing;Zhou, Wen;Yu, Jing;Zhang, Yi;Liu, Quan US2017/313683, 2017, A1 Location in patent:Paragraph 1046-1047
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148473-84-1
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![Carbonic acid, bis(1,1-dimethylethyl) ester](/CAS/20180601/GIF/34619-03-9.gif)
34619-03-9
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![tert-butyl 3-hydroxyazepane-1-carboxylate](/CAS/20150408/GIF/478841-10-0.gif)
478841-10-0
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$175.00/100mg
![Pentanoic acid, 5-[(2-ethoxy-2-oxoethyl)(phenylmethyl)amino]-, ethyl ester](/CAS/20200611/GIF/478841-07-5.gif)
478841-07-5
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![tert-butyl 3-hydroxyazepane-1-carboxylate](/CAS/20150408/GIF/478841-10-0.gif)
478841-10-0
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![ethyl 1-benzyl-3-oxoazepane-4-carboxylate](/CAS/20200401/GIF/478841-09-7.gif)
478841-09-7
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![tert-butyl 3-hydroxyazepane-1-carboxylate](/CAS/20150408/GIF/478841-10-0.gif)
478841-10-0
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![1-BENZYL-3-OXOAZEPANE](/CAS/GIF/146407-32-1.gif)
146407-32-1
64 suppliers
$75.00/50mg
![tert-butyl 3-hydroxyazepane-1-carboxylate](/CAS/20150408/GIF/478841-10-0.gif)
478841-10-0
40 suppliers
$175.00/100mg