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ChemicalBook CAS DataBase List ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE

ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux
2.1: magnesium / tetrachloromethane; ethanol / 3.25 h / Reflux
2.2: 2.33 h / -10 °C
3.1: toluene-4-sulfonic acid / water / 5 h / Reflux

References:

Huang, Ju;Wang, Minghua;Wang, Bin;Wu, Zhaoyang;Liu, Mingliang;Feng, Lianshun;Zhang, Jun;Li, Xiaoning;Yang, Yang;Lu, Yu [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 9,p. 2262 - 2267]

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