![](/CAS/20180629/GIF/1027995-71-6.gif)
3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester synthesis
- Product Name:3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester
- CAS Number:1027995-71-6
- Molecular formula:C15H21NO3
- Molecular Weight:263.33
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
425 suppliers
$10.00/10g
![1-N-Boc-3-hydroxyazetidine](/CAS/GIF/141699-55-0.gif)
141699-55-0
386 suppliers
$6.00/1g
![3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester](/CAS/20180629/GIF/1027995-71-6.gif)
1027995-71-6
31 suppliers
$495.11/5MG
Yield:1027995-71-6 89.9%
Reaction Conditions:
with sodium hydride in tetrahydrofuran;mineral oil at 20; for 16 h;
Steps:
50.1 Step 1:
tert-butyl 3-(benzyloxy)azetidine-1-carboxylate
A mixture of tert-butyl 3-hydroxyazetidine-1-carboxylate (3.0 g, 17.32 mmol), benzyl bromide (3.55 g, 20.78 mmol) and sodium hydride (60% in mineral oil, 1.04 g, 25.98 mmol) in tetrahydrofuran (30 mL) was stirred at room temperature for 16 h.
The reaction was quenched with water (20 ml), and ethyl acetate (50 mL*3) was added for extraction.
The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated.
The residue was purified by flash chromatography (ethyl acetate/petroleum ether=0-30%) to give tert-butyl 3-(benzyloxy)azetidine-1-carboxylate 0135A (4.1 g, 89.9%) in the form of a colorless oil. LCMS (ESI) [M-56+H]+=208.2; [M+Na]+=286.21.837 min (Method A).
References:
US2020/369676,2020,A1 Location in patent:Paragraph 1144-1145
![Benzyl chloride](/CAS/GIF/100-44-7.gif)
100-44-7
630 suppliers
$13.50/250G
![1-N-Boc-3-hydroxyazetidine](/CAS/GIF/141699-55-0.gif)
141699-55-0
386 suppliers
$6.00/1g
![3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester](/CAS/20180629/GIF/1027995-71-6.gif)
1027995-71-6
31 suppliers
$495.11/5MG
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester](/CAS/20180629/GIF/1027995-71-6.gif)
1027995-71-6
31 suppliers
$495.11/5MG
![tert-Butyl 3-oxoazetidine-1-carboxylate](/CAS/GIF/398489-26-4.gif)
398489-26-4
423 suppliers
$9.00/5g
![3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester](/CAS/20180629/GIF/1027995-71-6.gif)
1027995-71-6
31 suppliers
$495.11/5MG