Carbamic acid, N-[10,11-dihydro-5-[2-(methylamino)acetyl]-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester synthesis

4synthesis methods

Product Name:Carbamic acid, N-[10,11-dihydro-5-[2-(methylamino)acetyl]-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester
CAS Number:102821-92-1
Molecular formula:C20H23N3O3
Molecular Weight:353.41

[5-(2-CHLORO-ACETYL)-10,11-DIHYDRO-5 H-DIBENZO[ B , F ]AZEPIN-3-YL]-CARBAMIC ACID METHYL ESTER

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Carbamic acid, N-[10,11-dihydro-5-[2-(methylamino)acetyl]-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester

102821-92-1
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Yield:102821-92-1 46%

Reaction Conditions:

with methylamine in toluene;

Steps:

15 Preparation of 3-carbethoxyamino-5-methylamino-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine

EXAMPLE 15 Preparation of 3-carbethoxyamino-5-methylamino-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine 2.4 g, 0.006 moles of 3-carbmethoxyamino-5-chloroacetyl-10,11-dihydro-5H-dibenz[b,f]azepine (hereafter referred to as "Startazepine 3") is shaken with 1.2 g (0.04 moles) of methylamine in 30 ml of toluene for 3 hours in an autoclave at 40° C. to 50° C. and is subsequently heated for 4 hours at 150° C. to 155° C. After working it up, and precipitation of a hydrochloride in toluene with ethereal HCl, 1,2 g, corresponding to 46% of the theoretical yield, are obtained, having a melting point of 254° C. to 256° C.

References:

US5116974,1992,A

10464-35-4 Synthesis

10,11-Dihydro-5H-dibenzo[b,f]azepin-3-aMine

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References

84803-67-8
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References

ethyl 10,11-dihydro-5H-dibenzo[b,f]azepin-3-ylcarbamate

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102821-92-1
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References