ChemicalBook CAS DataBase List 7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077)

7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077) synthesis

5synthesis methods

Product Name:7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077)
CAS Number:1037627-94-3
Molecular formula:C15H22N2
Molecular Weight:230.35

1-(2-NITRO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-7-YL)PYRROLIDINE

1037627-93-2
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7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine(WXC08077)

1037627-94-3
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Yield:1037627-94-3 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol; under 2068.65 Torr; for 1 h;

Steps:

4

SYNTHETIC PREPARATION 4. Synthesis of 7-(pyrrolidin-1 -yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine Compound of formula (Ba). A mixture of 1-(2-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)pyrrolidine (2.0 g; 7.69 mmol) and 10% palladium on carbon (0.2 g, -50% water) in methanol (150 mL) was shaken under hydrogen (40 psi) for 1 h. After this time the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine as an oil (quantitative yield); MS (m/e): 231 (M+H⁺).

References:

WO2008/83367,2008,A2 Location in patent:Page/Page column 134

91-13-4
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1037627-94-3
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24790-66-7
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References

37949-03-4 Synthesis

8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one

37949-03-4
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1037627-94-3
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References

2-nitro-8,9-dihydro-5H-benzo[7]annulen-7(6H)-one

740842-50-6
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$200.00/100mg

1037627-94-3
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References