3-(6-BROMOPYRIDIN-2-YL)-6-CHLOROIMIDAZO[1,2-A]PYRIDINE synthesis

1synthesis methods

Product Name:3-(6-BROMOPYRIDIN-2-YL)-6-CHLOROIMIDAZO[1,2-A]PYRIDINE
CAS Number:1044733-65-4
Molecular formula:C12H7BrClN3
Molecular Weight:308.56

626-05-1 Synthesis

626-05-1
498 suppliers
$9.00/10g

885275-59-2 Synthesis

885275-59-2
72 suppliers
$41.00/250mg

3-(6-BROMOPYRIDIN-2-YL)-6-CHLOROIMIDAZO[1,2-A]PYRIDINE

1044733-65-4
30 suppliers
$78.00/100mg

Yield:-

Reaction Conditions:

Stage #1:6-chloro-3-iodoimidazo[1,2-a]pyridine with isopropylmagnesium chloride in tetrahydrofuran at -78;Grignard reaction;
Stage #2: with tributyltin chloride in tetrahydrofuran at -78 - 20;
Stage #3:2,6-Dibromopyridine with tetrakis(triphenylphosphine) palladium⁽⁰⁾ in tetrahydrofuran at 140;Microwave irradiation;Stille coupling;

References:

Buckley, George M.;Fosbeary, Richard;Fraser, Joanne L.;Gowers, Lewis;Higueruelo, Alicia P.;James, Lynwen A.;Jenkins, Kerry;Mack, Stephen R.;Morgan, Trevor;Parry, David M.;Pitt, William R.;Rausch, Oliver;Richard, Marianna D.;Sabin, Verity [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 12,p. 3656 - 3660] Location in patent:scheme or table