![](/CAS/20180703/GIF/1044870-30-5.gif)
2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE synthesis
- Product Name:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE
- CAS Number:1044870-30-5
- Molecular formula:C18H18N2O4
- Molecular Weight:326.35
![3,5-Dimethyl-4-hydroxybenzaldehyde](/CAS/GIF/2233-18-3.gif)
2233-18-3
228 suppliers
$6.00/5g
![2-aMino-4,6-diMethoxybenzaMide](/CAS/GIF/63920-73-0.gif)
63920-73-0
65 suppliers
$50.00/50mg
![2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE](/CAS/20180703/GIF/1044870-30-5.gif)
1044870-30-5
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Yield:1044870-30-5 79%
Reaction Conditions:
with toluene-4-sulfonic acid;sodium hydrogensulfite in N,N-dimethyl acetamide at 120; for 16 h;
Steps:
2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one(RVX-OH).
Aniline 12 (37 mg, 0.188 mmol) and4-hydroxy-3,5-dimethylbenzaldehyde (13a)(28.3 mg, 0.188 mmol) were dissolved inDMAc (1.0 mL) and treated with sodiumhydrogen sulfite (23.5mg, 0.23 mmol) and PTSA (7.2 mg, 0.04 mmol).The reactionmixture was stirred at 120 °C for 16 h. Water was added tothereaction, and the precipitated solid was collected by filtrationto giveRVX-OH (49 mg, 79%).
References:
Shao, Mingfeng;He, Linhong;Zheng, Li;Huang, Lingxiao;Zhou, Yuanyuan;Wang, Taijing;Chen, Yong;Shen, Mingsheng;Wang, Fang;Yang, Zhuang;Chen, Lijuan [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 17,p. 4051 - 4055] Location in patent:supporting information
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21544-81-0
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$52.00/250mg
![2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE](/CAS/20180703/GIF/1044870-30-5.gif)
1044870-30-5
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10272-07-8
421 suppliers
$6.00/1g
![2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE](/CAS/20180703/GIF/1044870-30-5.gif)
1044870-30-5
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![2-AMINO-4,6-DIMETHOXY-BENZOIC ACID](/CAS/GIF/21577-57-1.gif)
21577-57-1
112 suppliers
$20.00/250mg
![2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE](/CAS/20180703/GIF/1044870-30-5.gif)
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40891-33-6
21 suppliers
$945.00/500g
![2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE](/CAS/20180703/GIF/1044870-30-5.gif)
1044870-30-5
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