TERT-BUTYL 8-BROMO-2,3-DIHYDROBENZO[F][1,4]OXAZEPINE-4(5H)-CARBOXYLATE synthesis

3synthesis methods

Product Name:TERT-BUTYL 8-BROMO-2,3-DIHYDROBENZO[F][1,4]OXAZEPINE-4(5H)-CARBOXYLATE
CAS Number:1055880-16-4
Molecular formula:C14H18BrNO3
Molecular Weight:328.2016

1445903-00-3 Synthesis

Carbamic acid, N-[(4-bromo-2-hydroxyphenyl)methyl]-N-(2-hydroxyethyl)-, 1,1-dimethylethyl ester

1445903-00-3
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TERT-BUTYL 8-BROMO-2,3-DIHYDROBENZO[F][1,4]OXAZEPINE-4(5H)-CARBOXYLATE

1055880-16-4
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Yield:1055880-16-4 86%

Reaction Conditions:

with di-isopropyl azodicarboxylate;triphenylphosphine in dichloromethane at 20; for 12 h;

Steps:

11.2 Step 2: ferf-Butyl 8-bromo-2.3-dihydrobenzo[ ][1.4]oxazepine-4(5H)-carboxylate

Step 2: ferf-Butyl 8-bromo-2.3-dihydrobenzo[ ][1.4]oxazepine-4(5H)-carboxylate [01] To a solution of teri-butyl N-[(4-bromo-2-hydroxy-phenyl)methyl]-N-(2- hydroxyethyl)carbamate (3 g, 8.67 mmol) and triphenylphosphine (3.4 g, 13.0 mmol) in dichloromethane (85 mL) was added diisopropyl azodicarboxylate (2.69 g, 13.0 mmol) and the reaction was stirred at ambient temperature for 12 hours. The reaction was then washed with water, brine, dried with MgS0₄ and purified by silica gel column chromatography (0-40% EtOAc in heptane) to give teri-butyl 8-bromo-2,3- dihydrobenzo[ ][l,4]oxazepine-4(5H)-carboxylate (2.45 g, 86% yield). LCMS (m/z) ES⁺ 328 [M+l]⁺.

References:

WO2013/92941,2013,A1 Location in patent:Page/Page column 55

24424-99-5 Synthesis

24424-99-5
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8-BroMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine hydrochloride

1352707-91-5
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1055880-16-4
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References

22532-62-3 Synthesis

22532-62-3
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$5.00/250mg

1055880-16-4
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References