ChemicalBook CAS DataBase List 1(2H)-Phthalazinone, 4-[(3-bromo-4-fluorophenyl)methyl]-

1(2H)-Phthalazinone, 4-[(3-bromo-4-fluorophenyl)methyl]- synthesis

12synthesis methods

Product Name:1(2H)-Phthalazinone, 4-[(3-bromo-4-fluorophenyl)methyl]-
CAS Number:1062292-60-7
Molecular formula:C15H10BrFN2O
Molecular Weight:333.16

3-(3-BROMO-4-FLUOROBENZYL)ISOBENZOFURAN-1(3H)-ONE

63964-50-1
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1(2H)-Phthalazinone, 4-[(3-bromo-4-fluorophenyl)methyl]-

1062292-60-7
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Yield:1062292-60-7 94%

Reaction Conditions:

Stage #1: 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)-1-bromobenzenewith sodium ethanolate in ethanol; for 1 h;Reflux;
Stage #2: with hydrogenchloride;hydrazine hydrate in water; pH=1; for 3 h;pH-value;

Steps:

2.1.b

b, adding compound IV28.76g to the reaction flask,Sodium ethoxide 0.09 mol, ethanol 200 ml,The reaction was stirred under reflux for 1 h, and 10% hydrochloric acid was added to adjust the pH to 1,Add 5.87ml of 80% (mass fraction) hydrazine monohydrate,The reaction was stirred for 3 h, filtered, washed with water and dried in vacuo.The yield was 94% and the purity was 99.95%.

References:

CN108586355,2018,A Location in patent:Paragraph 0032; 0036; 0039

61260-15-9 Synthesis