Methyl 2-(2-bromo-4,5-dimethoxyphenyl)-2-methylpropanoate synthesis
1synthesis methods
- Product Name:Methyl 2-(2-bromo-4,5-dimethoxyphenyl)-2-methylpropanoate
- CAS Number:1069115-22-5
- Molecular formula:C13H17BrO4
- Molecular Weight:317.18
Yield:1069115-22-5 98%
Reaction Conditions:
Stage #1: methyl 2-(2-bromo-4,5-dimethoxyphenyl)acetatewith lithium hexamethyldisilazane in tetrahydrofuran at 25; for 2 h;
Stage #2: methyl iodide in tetrahydrofuran at 25;
References:
?arny, Tomá?;Baudoin, Olivier;Clemenceau, Antonin;Rocaboy, Ronan [Angewandte Chemie - International Edition,2020,vol. 59,# 43,p. 18980 - 18984][Angew. Chem.,2020,vol. 132,# 43,p. 19142 - 19146,5] Location in patent:supporting information