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4-(3-AMino-pyridin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation
2: palladium 10% on activated carbon / ethanol; tetrahydrofuran / 7 h / 20 °C / Inert atmosphere

References:

KISSEI PHARMACEUTICAL CO., LTD. EP3808747, 2021, A1