5-Thiazolecarboxylic acid, 2-chloro-4-(4-methoxy-2-pyrimidinyl)-, methyl ester synthesis

6synthesis methods

Product Name:5-Thiazolecarboxylic acid, 2-chloro-4-(4-methoxy-2-pyrimidinyl)-, methyl ester
CAS Number:1093115-02-6
Molecular formula:C10H8ClN3O3S
Molecular Weight:285.71

1093115-03-7 Synthesis

5-Thiazolecarboxylic acid, 2-amino-4-(4-methoxy-2-pyrimidinyl)-, methyl ester

1093115-03-7
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5-Thiazolecarboxylic acid, 2-chloro-4-(4-methoxy-2-pyrimidinyl)-, methyl ester

1093115-02-6
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Yield:1093115-02-6 62%

Reaction Conditions:

with hydrogenchloride;acetic acid;sodium nitrite in water at 0 - 20; for 1.16667 h;

References:

Basarab, Gregory S.;Hill, Pamela J.;Garner, C. Edwin;Hull, Ken;Green, Oluyinka;Sherer, Brian A.;Dangel, P. Brian;Manchester, John I.;Bist, Shanta;Hauck, Sheila;Zhou, Fei;Uria-Nickelsen, Maria;Illingworth, Ruth;Alm, Richard;Rooney, Mike;Eakin, Ann E. [Journal of Medicinal Chemistry,2014,vol. 57,# 14,p. 6060 - 6082] Location in patent:supporting information

463337-53-3 Synthesis

Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI)

463337-53-3
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References

2-Pyrimidinepropanoic acid, 4-methoxy-β-oxo-, methyl ester

1093115-04-8
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1093115-02-6
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References

89640-54-0 Synthesis

89640-54-0
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1093115-02-6
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References

22536-63-6
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$14.00/1g

1093115-02-6
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References