![](/CAS/GIF/1095565-81-3.gif)
(5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone synthesis
- Product Name:(5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone
- CAS Number:1095565-81-3
- Molecular formula:C14H22N2OS
- Molecular Weight:266
![4(5H)-Thiazolone, 2-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-ylaMino]-5-Methyl-5-(1-Methylethyl)-, (5S)- (Methanesulfonate)](/CAS/GIF/1095565-87-9.gif)
1095565-87-9
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![(5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone](/CAS/GIF/1095565-81-3.gif)
1095565-81-3
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Yield:1095565-81-3 95.1%
Reaction Conditions:
with sodium hydroxide;water in dichloromethane; for 1 h;Purification / work up;
Steps:
7.4
Step 4 (Free basing); [0154] To a 40 g suspension of MSA salt (20) in DCM (1OX, 40OmL) in a 1000 mL, 3 neck round bottom flask, equipped with a mechanical stirrer and a nitrogen inlet, was added 5X of IN NaOH (200 mL). The mixture was stirred for 1 hour and transferred to a separatory funnel. The layers were allowed to settle for 15 minutes and then split. The organic layer was then washed with 5 volumes of DI water until the pH of the aqueous layer was neutral. The organic layer (DCM) is filtered through a medium fritted glass filter prior to proceeding with the solvent exchange.
References:
WO2009/2445,2008,A1 Location in patent:Page/Page column 47-48
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