Methyl 2-((1r,4r)-4-(4-(4-chloro-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetate synthesis

1synthesis methods

Product Name:Methyl 2-((1r,4r)-4-(4-(4-chloro-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetate
CAS Number:1109276-87-0
Molecular formula:C22H26N4O4
Molecular Weight:410.47

1109277-49-7 Synthesis

Methyl 2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetate

1109277-49-7
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Methyl 2-((1r,4r)-4-(4-(4-chloro-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetate

1109276-87-0
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Yield:1109276-87-0 100%

Reaction Conditions:

with ammonia in 1,4-dioxane at 25;

References:

Dow, Robert L.;Li, Jian-Cheng;Pence, Michael P.;Gibbs, E. Michael;Laperle, Jennifer L.;Litchfield, John;Piotrowski, David W.;Munchhof, Michael J.;Manion, Tara B.;Zavadoski, William J.;Walker, Gregory S.;McPherson, R. Kirk;Tapley, Susan;Sugarman, Eliot;Guzman-Perez, Angel;Dasilva-Jardine, Paul [ACS Medicinal Chemistry Letters,2011,vol. 2,# 5,p. 407 - 412] Location in patent:scheme or table