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Difluoro-(4-Methoxy-phenyl)-acetic acid ethyl ester synthesis

12synthesis methods
-

Yield:112545-98-9 81%

Reaction Conditions:

with bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)];tetrabutylammomium bromide;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;zinc in tetrahydrofuran at 60; for 12 h;Inert atmosphere;

References:

Xia, Tingting;He, Lei;Liu, Yahu A.;Hartwig, John F.;Liao, Xuebin [Organic Letters,2017,vol. 19,# 10,p. 2610 - 2613] Location in patent:supporting information