ChemicalBook CAS DataBase List Ethyl 2-phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole-4-carboxylate

Ethyl 2-phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole-4-carboxylate synthesis

1synthesis methods

Product Name:Ethyl 2-phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole-4-carboxylate
CAS Number:1126530-82-2
Molecular formula:C14H14F3NO3
Molecular Weight:301.26

(Z)-Ethyl 2-benzaMido-4,4,4-trifluorobut-2-enoate

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1774-47-6 Synthesis

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Ethyl 2-phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole-4-carboxylate

1126530-82-2
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Yield:1126530-82-2 31%

Reaction Conditions:

Stage #1: trimethylsulfoxonium iodidewith sodium hydride in dimethyl sulfoxide;mineral oil at 20; for 0.5 h;
Stage #2: (Z)-ethyl 2-benzamido-4,4,4-trifluorobut-2-enoate in dimethyl sulfoxide;mineral oil at 20; for 72 h;

References:

Wan, Wen;Gao, Yinghong;Jiang, Haizhen;Hao, Jian [Journal of Fluorine Chemistry,2008,vol. 129,# 6,p. 510 - 514] Location in patent:experimental part