ChemicalBook CAS DataBase List (R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile synthesis

5synthesis methods

Product Name:(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CAS Number:1146629-83-5
Molecular formula:C11H14BrN3
Molecular Weight:268.15

4630-80-2 Synthesis

4630-80-2
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(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

1146629-83-5
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 15 h / 70 °C
2: NADPH; D-glucose; potassium dihydrogenphosphate / dimethyl sulfoxide / 32 h / 25 - 35 °C / Enzymatic reaction
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 - 35 °C / Inert atmosphere

References:

Shanghai Bei Ka Pharmaceutical Co., Ltd.;Wang Yong;Liu Ligang;Xiang Jie;Yang Shiqiong;Li Qian;Kang Litao CN104496904, 2017, B