Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate synthesis
- Product Name:Diisopropyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate
- CAS Number:115118-68-8
- Molecular formula:C14H24O6
- Molecular Weight:288.34
22094-18-4
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115118-68-8
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Yield:115118-68-8 90%
Reaction Conditions:
with sodium hydride at 70; for 24 h;Reflux;
Steps:
1 Example one
Slowly add diisopropyl malonate (37.6g, 0.2mol) to the solution of sodium hydride (8.8g, 0.22mol) in DMF (75mL), keeping the temperature below 70, and then add 3-dibromo-2 , 2-Dimethoxypropane (26.2g, 0.1mol), heated to reflux reaction for 24h, after the reaction is complete, cool down, add ammonium chloride solution, extract with n-hexane, wash with water, wash with sodium bicarbonate, dry with anhydrous sodium sulfate, Concentrated to obtain 26 g of compound I (90% yield).
References:
CN111320535,2020,A Location in patent:Paragraph 0043-0045
13195-64-7
281 suppliers
$5.00/10g
153214-82-5
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$60.00/50mg
115118-68-8
144 suppliers
$13.00/1g
22094-18-4
309 suppliers
$5.00/1g
115118-68-8
144 suppliers
$13.00/1g